Aminoacyl-tRNA (also aa-tRNA or charged tRNA) is tRNA to which its cognate amino acid is chemically bonded (charged). The aa-tRNA, along with particular elongation factors, deliver …

The aminoacyl–AMP, which remains bound to the enzyme, is transferred to a specific molecule of tRNA in a reaction catalyzed by the same enzyme. AMP…

The aminoacyl-tRNA synthetases catalyze a two-step reaction that leads to the esterification of an amino acid to the 3′ end of a tRNA along with the hydrolysis of one molecule of ATP, yielding …

In this sequence the amino acid first reacts with adenosine triphosphate (ATP) to form aminoacyl-AMP and pyrophosphate. The aminoacyl-AMP binds to tRNA to produce the charged tRNA …

Oct 7, 2024 · Below, we provide an overview of the many functions of aminoacyl-tRNA synthetases — from their role in translation, one of the most fundamental processes of all life, …

Sep 30, 2023 · The activated aminoacyl group is then transferred from the adenylate to the 3′ end of the tRNA to form aa–tRNA. This also releases AMP and the aminoacyl-tRNA synthetase …

Aminoacyl-amp is a complex, comprising of an activated amino acid linked to the phosphate group of AMP. The amino acid, that is responsible to begin the assembly of protein chain, is …

First, the carboxyl group of the backbone of the amino acid is covalently linked to the α-phosphate of the ATP molecule, releasing inorganic pyrophosphate (PP i) and creating a 5’ aminoacyl …

First, the amino acid forms a covalent bond to an adenine nucleotide, producing an aminoacyl-AMP. The free energy of hydrolysis of ATP provides energy for bond formation.

In a first step, the L-amino acid is activated by ATP and forms an aminoacyl- AMP, by a reaction analogous to that of the activation of fatty acids where an acyl-AMP is formed (see fig. 5-10).