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  1. May 21, 2022 · A hypothesis is an educated guess or statement about the relationship between 2 or more variables 2,3. Scientific hypothesis generation is a critical step in scientific research that …

  2. Hypothesis-generating analysis of mutational signatures in childhood …

    Oct 9, 2025 · Clock-like signatures show associations with parental and patient age as well as SES, potentially indicating some age-dependent differences. These results should inform future etiologic …

  3. Hypothesis-driven patterns of intracranial exploration in ... - medRxiv

    Jul 22, 2024 · Using semiological observations and a detailed cytoarchitectonic analysis, we propose a novel hypothesis classification system of four hypotheses in TLE and describe this in detail.

  4. A comparison of two open-source methods for molecular phylogenetic ...

    Sep 30, 2025 · A comparison of two open-source methods for molecular phylogenetic analysis of Human Immunodeficiency Virus (HIV): Hypothesis testing using Phylogenetics (HyPhy) and …

  5. Estimating Blood Pressure from the Electrocardiogram: Findings of a ...

    Jul 25, 2025 · Approach In this study, machine-learning (ML) models were developed to explore this hypothesis by estimating BP from 30-second ECGs using an extensive dataset from AliveCor Inc., …

  6. COVID-19 Origins: Quantifying Scientific Consensus Amid Political ...

    Jun 12, 2025 · The lab leak hypothesis, which involves an escape of the virus from WIV laboratory in Wuhan, China and the natural origin hypothesis possible through an intermediate host.

  7. Differentially Private Distributed Inference | medRxiv

    Mar 13, 2025 · The MLE setting has natural applications to binary hypothesis testing that we formalize with relevant statistical guarantees. Our results flesh out the nature of the trade-offs between the …

  8. Agentic AI for automated hypothesis testing in Alzheimer's disease …

    Dec 4, 2025 · Agentic AI for automated hypothesis testing in Alzheimer's disease and related dementias Ketan S. Saichandran, Karim Elzokm, Osman B. Guney, Vijaya B Kolachalama

  9. Neuromodulation with Ultrasound: Hypotheses on the Directionality of ...

    Jun 15, 2024 · Therefore, we conclude by establishing an Iowa-Newcastle (inTUS) resource for the systematic reporting of TUS parameters and outcomes to support further hypothesis testing for …

  10. Clinical validation of an RSV neutralization assay and testing of cross ...

    Jun 14, 2024 · The assay was then used to investigate the immunity debt hypothesis for resurgent RSV outbreaks in the 2022-2023 season. Study design We evaluated precision, sensitivity, specificity, …