The Role of CD40 in B Cell Activation and Immune Response
Jul 30, 2025 · The CD40-CD40L interaction promotes B cell proliferation, leading to a rapid increase in antigen-specific B cells. It also guides B cells to differentiate into plasma cells, the …
Molecular mechanism and function of CD40/CD40L engagement …
Once committed to the GC lineage, B cells encounter a specialized subset of activated Th cells called T follicular helper cells (T FH cells), that provide the necessary cytokine and cell-contact …
CD40L stimulates tumor-infiltrating B-cells and improves ex vivo …
Apr 8, 2025 · In this study, we characterized the association of tumor-infiltrating B-cells (TIL-B) and tertiary lymphoid structures (TLSs) with clinical response to TIL therapy and tested …
The Multifaceted Role of CD40 in Immunology
Jun 10, 2025 · B Cells: CD40 signaling is essential for B cell activation, proliferation, and differentiation. It promotes the expression of activation markers, such as CD80 and CD86, and …
Regulation of human B cell function by recombinant CD40 ligand …
Sep 1, 1995 · The signal provided by CD40L promotes aggregation of B cells, stimulates vigorous proliferation, and induces germ-line transcription of downstream heavy chain constant region …
Differential response of IgM and IgG memory B cell populations to CD40L …
Jul 10, 2024 · Memory B cells (mBCs) are characterized by their long-term stability, fast reactivation, and capability to rapidly differentiate into antibody-secreting cells (ASCs). …
The many applications of CD40-CD40L - News-Medical.net
Jul 1, 2025 · Its ligand, CD40 Ligand (CD40L), is primarily found on activated T cells. The interaction between CD40 and its ligand is crucial for immune responses such as B cell …
One such co stimulatory signal fpr B cells is a membrane-bound molecule on activated T cells called CD40 ligand (CD40L) (4). A number of critical molecular events involving CD40L occur …
CD40 Signaling Pathway - Abeomics
In human beings, mutations in CD40L lead to an impaired ability of B-Cells to undergo Ig class switching, abnormal antibody levels, and an inability to respond to certain bacterial infections.
What Is a CD40L Antibody and How Does It Work?
Dec 4, 2025 · By occupying the binding site, the antibody prevents CD40L from connecting with its receptor, CD40, on B cells and antigen-presenting cells. This blockage halts the …