Early-stage studies of medications to treat high-risk alcohol use may be missing opportunities to identify potential therapeutic effects in certain populations, including women and people at risk for ...

For hundreds of years, craving has been recognized as a central causal feature of addiction and relapse in overeating, gambling, and other addictions. But what causes craving, how one ends cravings, ...

Research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and ...

Dr. Michael Ascher invited Dr. Elana Rosof and Dr. Carrie Wilkens to coauthor this piece with him. For people in the early stages of making changes in their use of substances, engaging with loved ones ...

Addiction, or Substance Use Disorder (SUD), characterized by a dysregulation in the control of substance use is associated with frequent relapses despite efforts to cut-down or abstain from substance ...

John F. Kelly, PhD, of the Recovery Research Institute and Department of Psychiatry at Mass General Brigham, is the lead author of a paper published in Frontiers in Public Health, "Long-term relapse: ...

Every experience leaves a trace in the brain, a memory that can shape future behavior. Alcohol and other addictive substances are no exception. Over time, repeated alcohol use can create strong ...

John F. Kelly, PhD, of the Recovery Research Institute and Department of Psychiatry at Mass General Brigham, is the lead author of a paper published in Frontiers in Public Health, “Long-term relapse: ...

Research on the biological basis of addiction published in Biological Psychiatry uncovers the critical role that the HDAC5 enzyme plays in gene expression in the brain's epigenetic mechanisms that ...