A team of researchers at Kumamoto University has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease ...

Explore why tau still lacks treatments despite its critical role in Alzheimer's disease and other tauopathies.

The formation of aggregates due to protein misfolding and resulting protein instability is associated with several diseases. Previous studies have shown the potential of sulfobetaine polymer, a ...

Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson’s disease. The study, published today as ...

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...

Back when James Parkinson first described the disorder now known as Parkinson’s disease, he noticed that severe constipation can be a prelude to the signature tremors. In the 208 years since then, ...

An international research team reveals new molecular mechanisms associated with pathogenic mutations in the protein ...

Could measuring protein clumps in our cells be a new way to find out our risk of getting age-related diseases? Professor Dorothee Dormann and Professor Edward Lemke of Johannes Gutenberg University ...

Representative immunofluorescence image illustrating the neuroprotective effect of USP4 knockdown in iPSC-derived motor neurons (green) carrying an ALS-linked mutation. Inhibition of USP4 (EPS8 ...