When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, ...
The nuclear pore complex (NPC) is an essential, highly dynamic macromolecular assembly embedded in the nuclear envelope that orchestrates the precise exchange of proteins, RNA and other macromolecules ...
In situ model of the nuclear pore complex transport barrier: Tethered within the pore are highly dynamic protein threads termed FG Nups (green). Under physiological conditions, cargo-carrying ...
Nuclear pore complexes are more dynamic than previously thought, reshaping our understanding of a vital transport process in cells. An international study led by the University of Basel (Switzerland) ...
This is a preview. Log in through your library . Journal Information The Journal of Cell Biology (JCB) is a not-for-profit publication, edited by scientists, and a leading life sciences journal. The ...
A model of transport through the nuclear pore complex. The blue spheres represent macromolecules that do not interact with the selectively permeable barrier of the complex, while the red spheres ...
If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren't necessarily better: some cancer cells contain a dramatic excess of ...
The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies. As a SUMO E3 ligase, RANBP2 plays a pivotal role in ...
A new study by researchers at the VIB-UGent Center for Medical Biotechnology and collaborators demonstrates how a protein linked to the human immune system lures and traps HIV-1 and herpes simplex ...
Proteins are most well-known for their intricate structures. The α-helices and β-sheets that form from interactions between sidechains create distinct shapes that, along with the specific amino acid ...
When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, ...
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