Scientists at St. Jude Children's Research Hospital have shown how a protein responsible for adapting to low oxygen conditions (hypoxia), causes increased expression of fetal hemoglobin (HbF) in ...

Base editing—the genome editing technique that alters base pairs using a nuclease-deficient Cas9 fused to a deaminase—was found to restart fetal hemoglobin expression in sickle cell disease (SCD) ...

Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard found base editing increased fetal hemoglobin production in a new treatment for sickle cell disease and ...

Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease (SCD) and beta thalassemia. These two common life-threatening anemias afflict millions of individuals across ...

Researchers have unveiled a way to flip genes back on without slicing into the genome, a shift that could make CRISPR far ...

In the ever-evolving realm of modern medicine, a once-distant dream to conquer disease through genetics has now inched closer to reality. Last Friday, the U.S. Food and Drug Administration approved ...

Forbes contributors publish independent expert analyses and insights. William A. Haseltine, Ph.D., covers genomics and regenerative medicine A new chapter is unfolding for patients with sickle cell ...

Sickle cell anemia, a type of sickle cell disease (SCD), is a genetic condition that affects your red blood cells (RBCs). It affects around 100,000 Americans and is most common in people of African, ...

Vitreoscilla hemoglobin (VHb) has emerged as a pivotal tool in microbial biotechnology, offering a novel means of enhancing oxygen utilisation in a range of biological systems. Owing to its high ...

Space travel alters hemoglobin gene expression, increasing fetal globin production and shifting erythropoiesis to a primitive type. Low gravity in space increases the risk of coagulation disorders, ...