Human Argonaute 1 protein (cyan) bound to let-7 microRNA (magenta). Ago protein family plays a role in RNA silencing processes. Cartoon model with semi-transparent surface. Shutterstock | petarg ...
Argonaute proteins inhibit gene expression by binding to messenger RNA via a small nucleic-acid guide. Structures of the Argonaute complex bound to target RNA reveal snapshots of a silencing machine ...
Small RNAs (sRNAs) are loaded into ARGONAUTE (AGO) proteins to induce gene silencing. In plants, the 5′-terminal nucleotide is important for sRNA sorting into different AGOs. Here we show that ...
Scientists at the Max Planck Institute for Biology have discovered a remarkably streamlined strategy for developmental ...
Researchers at Indiana University Bloomington have uncovered previously hidden steps of a gene silencing process used to combat viruses and other would-be genome invaders. The new findings, published ...
Greg Hannon's group at Cold Spring Harbor Laboratory was one of many labs scrambling to identify Slicer, the enzyme doing the cutting in RNA-mediated interference. Using biochemical mutagenesis, in ...
Scientists identify protein motifs that influence gene silencing. Bioscientists at Heidelberg University have studied the function of certain proteins, known as Argonaute (Ago) proteins, in the ...
Research by Victor Ambros, Ph.D., provides new insights into a recently identified class of neurodevelopmental disorders called Argonaute syndromes. Dr. Ambros and colleagues believe their Proceedings ...
The Argonaute (Ago) enzyme complex plays a critical role in DNA and RNA target cleavage for a process known as RNA silencing in prokaryotic and eukaryotic cells, making them a target for future ...
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