Monitoring and maintaining a higher tacrolimus trough level in the first month after transplantation is essential to avoid acute rejection, according to investigators. Maintaining a tacrolimus trough ...

Transplantation of organs or tissues between genetically nonidentical individuals of the same species (and different species) is plagued by rejection and its associated problems. "Foreignness" is ...

The detection of collagen-degradation products in urine may enable the noninvasive diagnosis of acute rejection in renal transplant recipients, according to new findings. The researchers of this study ...

Researcher in lab Use of an assay that detects a novel urinary metabolite-based signature indicative of over-immunosuppression is among the innovative technologies being explored. Kidney biopsy ...

There are few comparisons of antibody induction therapy allowing early glucocorticoid withdrawal in renal-transplant recipients. The purpose of the present study was to compare induction therapy ...

THE continuing function of transplanted kidneys depends on the development of a degree of "tolerance" between graft and recipient and the judicious use of immunosuppressive therapy to further this ...

Significant advancements in solid organ transplantation immunosuppressive medications and regimens have resulted in improved outcomes over the years. A multidrug approach involving medications with ...

Northwestern University researchers have developed the first electronic device for continuously monitoring the health of transplanted organs in real time. Sitting directly on a transplanted kidney, ...

The transplantation of allogeneic skin grafts is associated with a potent inflammatory immune response leading to the destruction of donor cells and the rejection of the graft. Shortly after ...

Once a transplant patient gets past the first week to three months with their new organ, the risk of rejection drops substantially—at least for the first year. But over time, the immunosuppressants ...